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Because a mutation in the DJ-1 protein causes early onset of autosomal PD (Bonifati et al., 2003) and lower levels of DJ-1 are associated with PD, it is thought that drugs that up-regulate DJ-1 may slow disease progression by moderating oxidative stress and protein aggregation (Zhou et al., 2011)

In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment with two compounds, MI-09 or MI-30, significantly reduced lung viral loads and lung lesions

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Induce inflammation and cell death Endothelial inflammation is a crucial driver of AS

One fundamental division is between cytotoxic CD8 + T cells that kill pathogen-infected or malignant cells and helper CD4 + T cells