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Description
Given the role of the SMN in regulating neurotransmitter metabolism and cycling, experimental validation of multidrug approaches that systematically restore the SMN (targeting UMN/LMN dysfunction), while enhancing cortical motor inhibitory neurotransmission, may offer a novel translational perspective to preserve corticospinal homoeostasis in SMA patients

Andrews, D.L., Beames, B., Summers, M.D

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

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