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Thus, the impairment of these systems can lead to longer contact times of formulations, physiologic impairment and damage of the mucosa and the nasal epithelium

Chemical conjugation of epothilone with glutathione was studied, displaying a noticeable increasing of its anticancer activity towards various tumor cells [75], however, using several chemicals as cross-linkers for orienting the reaction, and checking the progress of reaction, and extra steps for purifying the conjugate is the major challenge

However, placebo effects can also add to early subjective reports, emphasizing the importance of objective measurements

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