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Somatomedin can generate and slow down telomere, and prolong cell life and human life

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In vitro glucose-induced cataract in copper-zinc superoxide dismutase null mice
The role of long non-coding RNAs in the development of adipose cells

Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective
