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A systematic literature review of Bentham, Scopus, PubMed, Medline, and EMBASE (Elsevier) databases was carried out to understand the Nature and mechanistic interventions of the -Lipoic acid for central nervous system diseases

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L-tryptophan can be obtained through dietary sources such as turkey, chicken, pumpkin seeds, spinach, milk, and bananas, but 5-Hydroxytryptophan is produced by the body and some people, therefore, find it beneficial to supplement this nutrient if their body is not producing enough

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These findings indicate that compared to other administration routes of vitamin B12, acupoint injection improves neurological function in patients with DN without increasing adverse events and economic burden, suggesting that it may be the optimal administration route for vitamin B12.