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Malonyl-CoA generated by acetyl-CoA carboxylase - isoform 2 (ACC2) binds with high affinity to each of the CPTI isoforms and acts like a switch to control the sensitivity to this key inhibitory molecule and regulate the transfer of fatty acids into the mitochondrial matrix and thence their oxidation

Normalization was carried out to account for technical variation, and keratins identified in blank Schirmer strip controls were removed, as previously published 30

As well as GR activity, oxidation by the three main pathways we have discussed in this review is situated within the context of glutathione synthesis and the vacuolar sequestration of a substantial part of the GSSG that is generated

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doi: 10.3389/fbioe.2020.00495 190 GopalTKumarNPerriotte-OlsonCCaseyCADonohueTMHarrisENet al