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Principal component analysis (PCA) revealed distinct transcriptional profiles between the WT and GR mutant strains (Figure 3A)

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An imbalance in these regulations leads to compromised barrier integrity and is linked with pathological conditions

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Acidic residues at the active sites of CD38 and ADP-ribosylt cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities