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19) was added at 10 M into the medium for 24 hours before harvest, with dimethyl sulfoxide or water added as vehicle control

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Additional neurologic findings such as developmental delay, seizures, hypotonia with or without neuromuscular disease manifestations, cognitive impairment, myopathy, and cranial nerve dysfunction have been reported in up to 29% of CVS patients allowing to propose a subtype called CVS plus (85)

Dosage: The dosage of levothyroxine is carefully calculated based on the individuals weight, age, and the severity of hormone deficiency, as well as other health conditions and medications