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Open Pathology J 3:3842 Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease

ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways

Several studies implementing similar study designs yielded non-significant findings (Wilkerson et al., 2012)

Loss of formimidoyltransferase cyclodeaminase (FTCD) stimulates the PPAR and SREBP2 signaling pathways, resulting in lipid buildup and hepatocarcinogenesis [44]

Siopis G, Colagiuri S, Allman-Farinelli M