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Aggregation also affects the mass balance of protein solutions, decreasing the concentration of the target protein

10.1523/JNEUROSCI.0986-17.2017 62 FerrarioV
Unfortunately, hardly any genetic markers have so far been identified as predictors of efficacy or ADRs that could be useful for the development of dosing guidelines [30]

[Google Scholar] 12.Bazzano LA, He J, Ogden LG, Loria CM, Vupputuri S, Myers L, et al

A generic protocol for the expression and purification of recombinant proteins in Escherichia coli using a combinatorial His6-maltose binding protein fusion tag
