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Without therapy, the outcome was the full monocrotaline syndrome, marked by right-side heart hypertrophy and massive thickening of the precapillary arterys smooth muscle layer, clinical deterioration, and sometimes death due to pulmonary hypertension and right-heart failure during the 4th week after monocrotaline injection

In clinical trials, the GLP1 in the brand name wegovy, has been found to lead to significant weight loss compared to placebo, as well as improve several metabolic markers such as blood pressure, lipid levels, and insulin resistance

Multicenter, placebo-controlled trial of lorcaserin for weight management