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Mechanistically, intranasally administered agents may be absorbed through the olfactory epithelium or trigeminal nerve endings and transported to the brain via extracellular diffusion and intracellular axonal pathways, which may partially bypass BBB-related constraints (Raghav et al., 2023

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41 Further studies also demonstrated that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional TJ regulation