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and (c) the olfactory nerve pathway where the drug is taken up into the neurons by endocytotic or pinocytotic mechanisms and transported by intracellular axonal transport to the olfactory bulb [2,16]

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Whether the chemotherapy-resistant clones existed in the initial cell population with the genetic mutations, whether molecular factors underlie the observed stem cell differentiation fate and whether the progression of the specific clone is conditional on the existence of any other clones are unanswered questions