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The cleavage of the scissile bond of substrates as oxytocin and vasopressin is anticipated to take place after a nucleophilic attack by water assisted by the carboxylate function of Glu465 in the active site of IRAP

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Up to now, mitophagy is considered as a selective form of autophagy to deliver dysfunctional or superfluous mitochondria to the lysosome for degradation, which has exhibited an essential contribution to cell homeostasis under different stimuli or cellular contexts, including cellular differentiation, oxidative stress response, and aging, as well as various disease conditions (Um and Yun, 2017