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One proposed hypothesis, as yet untested, is that high-dose folic acid supplements cause depletion of the transport protein holotranscobalamin in serum, thus exacerbating B12 deficiency

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doi: 10.1038/s41388-018-0203-6 102 ChenZYaoLLiuYZhuP

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Supplementing with curcumin has been shown to reduce inflammation and muscle damage brought on by exercise (107)