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When these measurements are high, that's a sign of both impaired mitochondrial function as well as poor metabolism and absorption of amino acids

Finally, a subset of ZIPs localized to intracellular membranes, such as ZIP7 in the ER, and ZIP9, ZIP11 and ZIP13 in the Golgi and ER, support organelle-specific zinc signaling, although their precise subcompartmental localizations remain areas of active investigation

identified FGF5 as an oncogenic growth factor and its methylation as a predictive marker for definitive chemoradiotherapy (dCRT) sensitivity from 117 ESCC patients, with low methylation linked to poor response (sensitivity 45%, specificity 90%), highlighting its potential clinical utility

Pontrello CG, McWhirt JM, Glabe CG, Brewer GJ

The results of the study by Lu et al