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VEGF operates primarily through VEGF receptor-2 (VEGFR-2/KDR/Flk-1), a tyrosine kinase receptor expressed predominantly on vascular endothelial cells

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2 Targeting iron ions and ROS to induce ferroptosis Studies have shown that various traditional Chinese medicines such as artemisinin and artemisinin can induce ferroptosis by increasing ROS content, thereby affecting iron metabolism, exerting anti-liver cancer effects and low toxicity, and are very promising drugs[9]

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2019;186:132 Ethics declarations Conflict of interest The authors declare no competing interests

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g/ml), followed by that in the liver, stomach wall, spleen, and thymus

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