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Manuscript source: Unsolicited manuscript Peer-review started: October 7, 2019 First decision: November 27, 2019 Article in press: January 19, 2020 Specialty type: Gastroenterology and hepatology Country of origin: Croatia Peer-review report classification Grade A (Excellent): 0 Grade B (Very good): 0 Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P-Reviewer: Dragoteanu MN S-Editor: Ma YJ L-Editor: A E-Editor: Wu YXJ Contributor Information Slaven Gojkovic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia

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Particles floating in the solution indicate incomplete dissolution or contamination