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Long-term use of NSAIDs can lead to gastrointestinal issues, cardiovascular problems, and kidney damage

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The results showed that the T4 eye drops improved ocular discomfort and increased tear volume compared to placebo.[ref] Bacterial eye infection: Using T4 along with an antibiotic improved the healing of infections in the cornea.[ref] Microneedle patch: An interesting clinical trial used TB4 in extracellular vesicles along with stem cells for healing diabetic wounds

That said, severe pain has been reported by some people, especially when bigger needles or medication doses are used