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The rectal route of administration can be particularly useful for patients who have difficulties with oral ingestion or for those who require a rapid onset of action
Patients typically present with an acute 3-4 g/dl drop in hemoglobin along with dark urine due to hemoglobinuria, elevated lactate dehydrogenase, and elevated reticulocyte count two to four days following an offending stressor
Increased oxidative stress in the fetus has been linked to preterm labor [72, 73]
