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JTC801 induces pH-dependent death specifically in cancer cells and slows growth of tumors in mice

and A.J., CBET 1337760 and CBET 0812381 to K.L.) and the NIH (1R21GM106251 to K.L

Altogether, the major efforts in managing NF1-related neoplasms have been based on drugs targeting signaling transduction cascades such as RTK, RAS- RAFMEKERK and PI3K-AKTmTOR inhibitors

Sox2 can upregulate neurogenin 1 (Neurog1) expression in otic progenitors and mediates neuronal differentiation in cooperation with the key transcription factors Eyes absent 1 (Eya1) and SIX homeobox 1 (Six1) that initiate the neuronal developmental program [96]

PMID: 58 SheteNCalabreseJTonettiDA