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Hence, senolytic therapies may be a suitable approach for increasing therapy sensitivity and preventing cancer relapse 10

Simultaneously, the ROS degrade the thioketal linker, releasing CPT and further enhancing localized cell death

In fact, the increased expression of glycolytic enzymes, such as HK2, which catalyze the first step in glucose metabolism, PFKFB, which plays a critical role in regulating glycolysis in the cytoplasm, and PDK1, a key enzyme that acts between glycolysis and tricarboxylic acid (TCA) cycle, supporting the idea that increased glycolysis could induce a more aggressive FLS phenotype 17,21,22,23