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These include- Aged over 75 Decreased stomach acid Frequent use of antacids Autoimmune conditions affecting the stomach High doses of folic acid Stomach surgery Prolonged use of metformin Adoption of a vegan or vegetarian diet Excessive alcohol consumption How Does Vitamin B12 Benefit Your Body
[DOI] [PubMed] [Google Scholar] 191.Cooke A, Tonks P, Jones FM, OShea H, Hutchings P, Fulford AJC, Dunne Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice

The results of long COVID investigations cautiously suggest that impaired metabolism and neuronal dysfunction may play a role in mental fatigue, similar to hypotheses for ME/CFS