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Because of this metabolic rewiring, cancer cells typically display the accumulation of abnormally high levels of lactate with consequent acidification of the tumor microenvironment (TME) and immunosuppression [3]

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HOMOCYSTEINE AND METHYLMALONIC ACID As we have seen, in anemia due to B12 deficiency, both homocysteine and methylmalonic acid are elevated, while in B9 deficiency (also a cause of megaloblastic anemia), only homocysteine is found in plasma levels above normal

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