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A case-control study indicated that a population of women with hypothyroidism continued to have a higher prevalence of anxiety or depression than a control group of euthyroid women, even after correction of TSH using LT4 [80]

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Senescence is characterized by a stable cell cycle arrest and multiple phenotypic changes, including the secretion of a wide array of pro-inflammatory cytokines, proteases, and other factors collectively known as the senescence-associated secretory phenotype (SASP) ( As several of the changes associated with senescence can also be observed in other cellular states, proper identification of cellular senescence requires the presence of multiple hallmarks

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139 Other inhibitors are also emerging, such as caudatan A, a novel human kidney-type glutaminase inhibitor with tetracyclic flavan, isolated from Ohwia caudata

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