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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

10.1016/s1474-4422(12)70238-7 Lancet Neurol

PMID 19713987

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For readers who want the clinical-outcomes companion to this mechanistic account, the sites overview of what clinical trials indicate about the fat-burning potential of AOD-9604 covers the human efficacy record in more depth