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This hypermethylation is driven by the upregulation of DNMT1 and DNMT3B in melanoma cells, DNMT1 mediates the maintenance of DNA methylation patterns during cell division, while DNMT3B promotes de novo methylation of the RIPK3 promoter, leading to stable and heritable silencing of the gene (98)

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Glutathion is de belangrijkste intracellulaire antioxidant en aanwezig in relatief hoge concentraties in alle lichaamscellen

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