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Cytochrome p450 oxidoreductase (POR) affects iron metabolism by removing hydrogen from polyunsaturated fatty acids, or by reducing Fe 3+ to Fe 2+ for electron transfer, to accelerate the circulation between Fe 3+ and Fe 2+ to promote ferroptosis (Zou et al., 2021)

Their findings were published in Nature Communications
10.1016/j.repbio.2012.10.001 43

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Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research