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[3] Cell Line:RBL-2H3 cells, human LAD2 mast cells Concentration:15 M Incubation Time:1 h Result:Inhibited S1P secretion by vector and SphK1 transfected RBL-2H3 cells, whereas it did not affect uptake and intracellular conversion of [3H]Sph to S1P

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In contrast, ACG arises from contact between the iris and the TM, obstructing AH outflow

International Journal of Molecular Sciences , 20 , 3479

Farnesyl-PP is a critical intermediate not only in cholesterol biosynthesis but also in the synthesis of coenzyme Q10, dolichol, and prenylated proteins, which are essential for mitochondrial function, intracellular signaling, and glycoprotein biosynthesis [27].Through a series of downstream reactions, mevalonate is transformed into isopentenyl pyrophosphate, an activated isoprene unit