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In addition, a meta-analysis of four clinical trials demonstrated that after three to 6 months of metformin use it significantly reduced vitamin B 12 levels [85]

As seen above, most potential drawbacks from vitamin B12 shots are ultimately minor, such as slight swelling or itchiness at the injection site

doi: 10.1074/jbc.275.4.2733

These results prompted the spread of oral administration in Sweden and Canada [3]
In both in-vitro and in-vivo experiments, methylcobalamin inhibited the proliferation of malignant cancerous cells