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New spines were preferentially added onto layer 5 pyramidal neurons with complex apical tufts, rather than those with simple tufts (Holtmaat et al., 2006)
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The protective effect of paeonol, a phenolic compound extracted from cortex moutan (tree peony bark), against H 2 O 2 -induced premature senescence in human umbilical endothelial cells is molecularly elucidated by a reduction in H 2 O 2 -induced upregulation of H3K14Ac and H4K16Ac, which subsequently enhances p53 proliferation through downregulation (Jamal et al., 2014)

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