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Furthermore, CYP3A1 emerges as one of the most significantly downregulated CYP450 isoforms under high-altitude exposure, suggesting gut microbiota as a key mediator of CYP3A1 modulationa plausible mechanism for hypoxia-driven microbial regulation of drug metabolism
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Interestingly, HIF-1-independent regulation of GSH synthesis has also been reported under hypoxia
