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Description
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Thus, any experiment with gene knockout mice needs to consider adaptive mechanisms that can affect signaling mechanisms and the mode of cell death
Several studies correlated high level of HCys to cardiovascular diseases, for example retrospective case-control studies showed that 10% of the all coronary artery disease is attributable to high HCys levels or that an increase of the blood level of HCys at 5 mol/l raises the risk of ischemic heart disease by 84% ( Figure 2 As an example, the accumulation of a HCys metabolite, the Homocysteine thiolactone (HTL), can be dangerous since, as a cyclic thioester with an esterified carboxyl group, it is highly reactive with the -NH 2 groups of the lysinic residues of proteins ( HHCys has several negative effects on the vascular system, including the alteration of endothelial function, which compromises the integrity of the vessel wall and in turn the vascular tone, leading to vascular inflammation ( HCys inhibits the production of NO in two ways, by the inhibition of NO synthase (eNOS) expression levels, supporting the over-expression of caveolin-1 that binds and inactivates eNOS (43)
Akhter, F., Chen, D., Akhter, A., Yan, S
