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Poly(ethylene glycol) in drug delivery: Pros and cons as well as potential alternatives
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These dogs were mostly neutered and were being fed a variety of quality commercial diets
However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71
