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10.1016/0006-8993(95)01454-3 118 WrightJ

Semax is not approved for human or veterinary use by the FDA or EMA

For a medicine to be switched to non-prescription status, it must be proven safe to use without medical supervision

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However, other heavier isoforms such as VEGF189 and VEGF206 remain bound to the ECM, with matrix-bound VEGF165, VEGF189, and VEGF206 all able to promote EC proliferation (172, 173)