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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

The TONIC (Treatment of NAFLD in Children) trial involved 173 children and adolescents witha mean age of 13 years that received metformin (500 mg twice daily), vitamin E (400 IU twice daily), or placebo twice daily for 96 weeks

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Noh and King, 2007), generation of AGEs, increased expression of TGF- and generation of ROS (Noh and King, 2007) that might eventually induce apoptotic death of cells