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From the analysis of crystal and cryo-electron microscopy (cryoEM) structural studies it was possible to confirm the role of IMiDs as MGDs, since their binding to cereblon generates a neomorphic surface that confers greater selectivity for a given neo-substrate, resulting from the establishment of IMiD-dependent interactions 51,207

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Yue Li, Tianjin University of Traditional Chinese Medicine, China Updates Copyright 2022 Sun, Zhao and Rong

10.1016/j.toxlet.2019.02.007 77 RamachandranA.JaeschkeH

Bar-Joseph, Z., Gifford, D
