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Conclusions In conclusion, this study demonstrates the positive therapeutic effect of intranasal GHK-Cu in transgenic 5xFAD mice, a widely used model for AD

However, its synthesis site remains unknown, and DSIP levels are equally abundant in peripheral tissues, suggesting functions beyond sleep regulation

The prototype drug could not be detected 4 h after administration, and its elimination half-life was less than 30 min

Its anti-inflammatory effects on NFkB a key mediator of age-related inflammatory disease and its DNA repair activity suggest potential relevance in broader regenerative medicine, though most of these applications remain under investigation

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