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Form: Injectable Solution

The initiation of RA by inflammation characterized by an aberrant Th-17-dominated immune response, neutrophil activation, antigen citrullination, and anti-cyclic citrullinated peptide (CCP) production is exacerbated by microbial dysbiosis, the presence of oral pathobionts (e.g., Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans ), and periodontitis has been described (165167)

Wong, S

These foods often contain trans fats, added sugars, and artificial preservatives that burden the liver, reducing its ability to produce and utilize glutathione for detoxification

doi: 10.3389/fnut.2025.1686777 Received 15 August 2025 Revised 15 November 2025 Accepted 28 November 2025 Published 12 January 2026 Volume 12 - 2025 Edited by Andrea Orellana-Manzano, Escuela Superior Politcnica del Litoral (ESPOL), Ecuador Reviewed by Paulina Cerda Opazo, Autonomous University of Chile, Chile Aliakbar Fazaeli, Ardabil University of Medical Sciences, Iran Updates Copyright 2026 Garutti, de Scordilli, Alberti, Mazzeo, Michelotti, Fagioli, Del Conte, Casirati, Caccialanza, Bartolini and Puglisi