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Melanogenesis can be regulated intrinsically by several signalling pathways, including the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA), stem cell factor (SCF)/c-kit and wingless-related integration site (Wnt)/-catenin signalling pathways

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Moreover, at 12 months, there was an even more robust association between area under the curve (AUC) glucose and AUC glucagon following a mixed-meal challenge

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10.1111/ene.14108 9 BjrklundG.PeanaM.MaesM.DadarM.SeverinB

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doi: 10.1016/j.eplepsyres.2012.10.011 172

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4 Causes and Risk Factors The precise cause of psoriasis is unknown

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