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Description
The heavy GCLC is both the catalytic unit and the regulatory site of GSH feedback inhibition, while the light subunit regulates the activity of the holo-enzyme by modulating the affinity of the two regulatory sites of GCLC, that for glutamate and that for glutathione thereby making the enzyme more efficient and less sensitive to feedback inhibition
doi:10.1158/1535-7163.MCT-14-0144
Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic depressive patients
W.Staurengo-FerrariL.Pinho-RibeiroF
Saklayen MG
