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The extreme clinical variability of NF1 disease suggests that random events intervene in determining the phenotype

The CCl4-treated group significantly reduced the antioxidant enzymes such as GSH, GST, Catalase and SOD

C JL, Aryal S, Ramirez MR, Wang J, Candeloro P, et al
Bioinformatics 27, 29572963

On the other hand, Nrf2-deficient mice have been shown to be susceptible to cigarette smoke-induced emphysema [265], hyperoxic lung injury [266], and pulmonary fibrosis [267]
