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Although both IRS are required for insulin-stimulated PDK1 phosphorylation of AKT1 at Thr308/Thr309 (AKT2), phosphorylation of both Thr308/Thr309 and Ser473 (AKT1)/Ser474 (AKT2) is required for maximal activity of AKT (Figure 1) (13, 76)

Together, these features reflect changes in the assembly, availability, and functional integrity of the OXPHOS complexes [163]

Mai BH, Yan LJ

Inflammatory Bowel Disease (IBD) encompasses two primary subtypes: Crohns disease (CD) and ulcerative colitis (UC)

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