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doi: 10.1016/j.peptides.2005.02.010

The defect begins below the receptor When insulin binds to its receptor, it initiates a signalling sequence through the phosphoinositide 3-kinase/Akt/mTOR pathway (PI3K/Akt/mTOR), which governs glucose transporter type 4 (GLUT4) translocation the step that allows glucose to actually enter the cell

Blood Sampling Blood samples were drawn from a participants antecubital vein, maintaining a sterile field and using BD Vacutainer tubes (Becton, Dickinson and Company, Franklin Lakes, NJ, USA) with serum-separator or ethylenediaminetetraacetic acid (EDTA)

The statistical data of the number of articles used for this study is shown in Figure 2

Piperlongumine decreases cell proliferation and the expression of cell cycle-associated proteins by inhibiting akt pathway in human lung cancer cells