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To further support the in vivo findings, we conducted in vitro coculture experiments that mimic the microenvironment of TLS (Supplemental Figure 10A)

These core Axin complex components (Kimelman and Xu, 2006) share a common goal of ensuring -catenin phosphorylation and degradation

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The various isoforms, ZO-1, ZO-2, and ZO-3, are all characterized by their ability to interact with different cellular proteins through a multitude of protein binding domains, such as the SH3 domain, the PDZ domain, and the leucine-zipper domain, 48,49 and are also essential for scaffold formation and the connection of other tight junction proteins to the cytoskeleton

Bev Donnelley , followed by an open Q&A with out team