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Therefore, these results suggested that sulindac selectively promoted the apoptosis of GABAergic neurons

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Additionally, the depletion of SCFA might result from an overgrowth of D-lactate producing bacteria, which are found at elevated levels in ME/CFS patients and have been studied previously [36]

Alternatives include swine iPS cell-derived CNS organoids and humanBBB combined systems, which offer physiological relevance and scalability, as well as ex vivo nonhuman primate brain slice cultures that provide anatomically accurate environments without the logistical or ethical challenges of in vivo studies