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A Balanced Act of Mitochondrial Biogenesis and Mitophagy Mitochondrial function is multifaceted in response to cellular energy homeostasis and metabolism, including calcium homeostasis, amino acid metabolism, pyridine synthesis, cellular replication, apoptosis, reactive oxygen species (ROS) production, and senescence (Spinelli and Haigis, 2018)

A well-developed organism has a primary interface between the CNS and the outer region of the body referred to as the bloodbrain barrier (BBB), which was discovered and named in the early twentieth century