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In addition, the released lactate can bind to the hydroxycarboxylic acid 1, HCA1 (encoded by the HCAR1 gene) receptor triggering autocrine effects in the adipocyte or paracrine effects in other cells

A study revealed that DPP9 promotes chemoresistance in liver cancer by binding to KEAP1, stabilizing Nrf2, and upregulating NQO1 expression to lower ROS and reduce chemotherapy efficacy

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High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial