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LINC00152 was among the most significantly upregulated, highly abundant, validated and oncogenic lncRNAs in tamoxifen resistant cells compared to parental counterparts (Fig

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The reasons for these variations are unclear and likely complex, but several stress-handling mechanisms such as autophagy and other ROS scavenging mechanisms may play a part

Moreover, these lactylation levels positively correlated with the expression of the Arg1 gene, indicating an association between histone lactylation modification and the M2 phenotype of tumor-associated macrophages