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Supplementation with GC in human and rodent studies results in increased glutathione, confirming biosynthesis of glutathione can occur without the first enzyme reaction (Reference Meister and Anderson75Reference Zarka and Bridge77)

Consistent with the observations made in the retrospective analyses, in this trial the ORR was 100% in the Lynch-like or mutational EC patients compared to 44% in the sporadic/ epigenetic ECs (p=0.024)

Nat Rev Drug Discov 2021

At the root of many of these issues is oxidative stress, a harmful process that occurs when theres an imbalance between free radicals and antioxidants in the body

Attenuation of oxidative DNA damage with a novel antioxidant EPC-K1 in rat brain neuronal cells after transient middle cerebral artery occlusion